'DNA Sequencing: Emerging Technologies and Applications' Market Study by Business Communications Company Inc.: published July 2010

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DNA Sequencing: Emerging Technologies and Applications

Table of Contents

Market Study
Published: July 2010
Pages: 297
Tables: 68
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Research from: Business Communications Company Inc.
Sector: Biotechnology

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This Report:

The worldwide market for sequencing products will grow from an estimated $1.3 billion in 2010 to more than $3.3 billion by 2015, a compound annual growth rate (CAGR) of 20.5% over the next 5 years.
Life-science research and drug discovery and development applications represent the two largest markets for DNA sequencing revenues, accounting for an estimated $920.1 million in 2010. These markets are forecast to grow at a compound annual growth rate (CAGR) of 13% to reach nearly $1.7 billion in 2015.
Emerging applications, including personal genomics and clinical diagnostics, are forecast to account for $541.4 million by the year 2015, an increase from $15.5 million in 2010 representing a 103.5% compound annual growth rate (CAGR).

INTRODUCTION

STUDY GOALS AND OBJECTIVES

BCC’s goal for this study is to determine the status of current and newer generation DNA (deoxyribonucleic acid) sequencing technologies, products and services and to assess their worldwide growth potential over a 5-year period from 2010 to 2015. Our particular interest is to characterize and quantify the DNA sequencing products market by application, technology, analysis type, geography, and end user. Sequencing applications market segments that will provide substantial future growth opportunities for next-generation DNA sequencing companies include research, drug discovery and development, bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Applications providing growth opportunities for genomics suppliers include sequence capture and bioinformatics.

Our main objective is to present a comprehensive discussion of DNA sequencing technologies; industry structure; key applications; major sequencing initiatives; global markets; intellectual property (IP) and patenting status; and sequencing companies. This discussion will assist life-science companies in strategic planning to meet the challenges and opportunities of this dynamic industry.

REASONS FOR DOING THE STUDY

The Human Genome Project (HGP) moved DNA sequencing technology to the forefront of life-science research as a genetic analysis tool. The HGP relied heavily on Sanger sequencing by capillary electrophoresis to decipher the DNA sequence of the bases in the human genome. A significant outcome of the HGP was improvements in the efficiency and costs of DNA sequencing. During this time period, the DNA sequencing industry consolidated, resulting in one dominant company, Applied Biosystems.

Beginning in 2005, new DNA sequencing technologies have emerged that are radically changing the structure of the industry and opening up exciting new market applications. Contributing to the rise of these new sequencing technologies are advances in nanotechnology, microfluidics, imaging, enzymology, and bioinformatics. Based on these market and technology dynamics, it is timely to examine the future DNA sequencing markets.

Ongoing discoveries in nanotechnology, bioinformatics, microfluidics, imaging, enzymology, and bioinformatics are revolutionizing many life-science fields, and providing novel platforms for next-generation DNA sequencing. At the same time this is occurring, there is a growing market demand for analysis of the genomes of many species and cancers and for understanding the role of genetic variation among individuals in disease. The genetic analysis industry seeks to meet these needs with tools such as microarrays, real-time polymerase chain reaction (RT-PCR), and DNA sequencing instruments.

Next-generation sequencing has created new opportunities to compete with traditional genetic analysis tools, and this report examines this trend and its significance for companies supplying DNA sequencing products and services.

Next-generation, and follow-on, third-generation DNA sequencing technologies will continue to change the dynamics of the DNA sequencing industry and create novel market opportunities. This report analyzes these trends and their impact on the future markets for DNA sequencing technologies.

Given the evolving nature of this industry, it is particularly timely to gain an understanding of these technological and competitive forces and the impact on the genetic analysis markets.

INTENDED AUDIENCE

We have compiled a study of next- and third-generation technologies that will be commercially important in the major end-user segments of life-science research, drug discovery and development, forensics and human identification, bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. We present both Sanger sequencing and follow-on-generation technologies as well as market growth driving forces, major sequencing initiatives, product formats, market applications, industry alliances, future market potential, and product sales forecasts for the period 2010 through 2015. We forecast the use of sequencing products for these end-user segments: major sequencing centers, academic genome centers, government labs, pharmaceutical/biotech labs, small to mid-size labs, and sequencing service labs.

This study will be of particular interest to life-science research tools suppliers, pharmaceutical, diagnostics, nanotechnology, bioinformatics, semiconductor, and biotechnology companies. It will also be valuable to companies involved in genome sequencing projects, sequencing centers, manufacturers of microarrays, suppliers of molecular diagnostics assays, bioinformatics companies, and cancer researchers and clinicians.

SCOPE OF REPORT

The study scope includes DNA sequencing technologies likely to be commercialized within the next 5 years. Sanger, next-generation, and third-generation technologies are included. Each technology is analyzed to determine its market status, impact on future market segments, and forecast growth from 2010 through 2015. Advantages and limitations of each technology together with market driving forces are discussed.

BCC examines the sequencing industry structure, strategic industry alliances and acquisitions, and sequencing patents. The strategies of the main sequencing companies are discussed. The markets for sequencing applications, including de novo whole-genome sequencing, resequencing, ChipSeq, MethylSeq, and RNASeq, are analyzed.

METHODOLOGY

BCC surveyed key users and producers in each of the market applications that will be commercially important during the next 5 years: research, drug discovery and development, forensics and human identification (ID), bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Based on our industry discussions and market analysis, we project the future applications of sequencing platforms and forecast sales revenues for 2010 through 2015.

The sequencing market is analyzed by technology, product type, application, customer, analysis type, geography, and genome type, with forecasts of market demand from 2010 through 2015. We analyze which applications and analyses will be important to the future of DNA sequencing, and the customer groups that will be consumers of the technologies. We also analyze the impact of other genetic analysis technologies like microarrays on the growth of sequencing.

CHAPTER ONE: INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THE STUDY

INTENDED AUDIENCE

SCOPE OF REPORT

METHODOLOGY

INFORMATION SOURCES

RELATED BCC REPORTS

ANALYST CREDENTIALS

BCC ONLINE SERVICES

DISCLAIMER

CHAPTER TWO: EXECUTIVE SUMMARY

SUMMARY TABLE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS) SUMMARY FIGURE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, 2009-2015 ($ MILLIONS)

CHAPTER THREE: OVERVIEW

INTRODUCTION

TABLE 1 SCOPE OF THIS REPORT

MARKET POTENTIAL OF DNA SEQUENCING PRODUCTS

TABLE 2 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)

SEQUENCING INDUSTRY GROWTH DRIVING FORCES

TABLE 3 DNA SEQUENCING KEY GROWTH DRIVING FORCES

SEQUENCING PRODUCTS

SEQUENCING INSTRUMENTS

SEQUENCING CONSUMABLES

SEQUENCING PRODUCT LIFE CYCLE STATUS

TABLE 4 PRODUCT LIFE CYCLE STATUS OF SEQUENCING PLATFORMS

COMMERCIAL STATUS

SEQUENCING INDUSTRY

TABLE 5 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY

CHAPTER FOUR: DNA SEQUENCING TECHNOLOGIES

GENETIC ANALYSIS

FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA

FIGURE 2 DNA, MRNA, AND GENETIC VARIATION

TABLE 6 SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIES

HISTORY OF DNA SEQUENCING

TABLE 7 DNA SEQUENCING HISTORICAL TIMELINE

FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED PER DOLLAR

FIGURE 4 SEQUENCING THROUGHPUT TREND

FIGURE 5 HUMAN GENOME SEQUENCING COST TREND, 2000-2015 (DOLLARS)

FIGURE 6 $1,000 GENOME PRODUCT SPACE

OVERVIEW OF SEQUENCING TECHNOLOGIES

TABLE 8 DNA SEQUENCING TECHNOLOGY PLATFORM COMPARISON

SANGER SEQUENCING

SANGER SEQUENCING TECHNOLOGY

FIGURE 7 DDNTP CHEMICAL STRUCTURE

FIGURE 8 SANGER SEQUENCING WORKFLOW

SANGER SEQUENCING COSTS

FIGURE 9 COST BREAKDOWN FOR SEQUENCING A SINGLE HUMAN GENOME, USING 2005 SANGER SEQUENCER TECHNOLOGY (%)

LIMITATIONS OF SANGER SEQUENCING

TABLE 9 LIMITATIONS OF SANGER SEQUENCING TECHNOLOGY

TECHNOLOGY DEVELOPMENTS IN SANGER SEQUENCING

TABLE 10 IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY

NEXT-GENERATION SEQUENCING TECHNOLOGIES

INTRODUCTION

NEXT-GENERATION SEQUENCING WORKFLOW

TABLE 11 NEXT-GENERATION SEQUENCING WORKFLOW STEPS

FIGURE 10 NEXT-GENERATION SEQUENCING TECHNOLOGIES

TABLE 12 WORKFLOW COMPARISON OF SELECTED NEXTGENERATION DNA SEQUENCING PLATFORMS

TABLE 13 NEXT-GENERATION SEQUENCE PLATFORMS

FIGURE 11 SCHEMATIC COMPARISON OF ROCHE/454, LIFE TECHNOLOGIES, AND ILLUMINA SEQUENCING PLATFORMS

TABLE 14 NEXT-GENERATION SEQUENCING PLATFORM ADVANTAGES AND LIMITATIONS

SEQUENCING BY SYNTHESIS WITH REVERSIBLE TERMINATORS

FIGURE 12 SEQUENCING BY SYNTHESIS: REVERSIBLE TERMINATOR REACTION

PYROSEQUENCING

FIGURE 13 SEQUENCING BY SYNTHESIS: PYROSEQUENCING REACTION

SEQUENCING BY LIGATION

Sample Preparation

Sequencing Reaction

FIGURE 14 SCHEMATIC OF SOLID SEQUENCING BY LIGATION

Cycle 1

Cycle 2

Cycles 3 to 5

Decoding

FIGURE 15 DECODING SOLID COLOR DATA

THIRD-GENERATION SEQUENCING

Single-molecule Sequencing by Synthesis

Nanopore Sequencing

FIGURE 16 SINGLE-MOLECULE SEQUENCING BY SYNTHESIS

FIGURE 17 NANOPORE SEQUENCING WORKFLOW AND TECHNOLOGY APPROACHES

SEQUENCING TECHNOLOGY PLATFORMS COMPARED

TABLE 15 KEY PERFORMANCE METRICS FOR SEQUENCING TECHNOLOGIES

TABLE 16 COST AND PERFORMANCE COMPARISON OF SELECTED NEXT- AND THIRD-GENERATION DNA SEQUENCING PLATFORMS

SEQUENCING PRODUCT LIFE CYCLE

TABLE 17 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES

SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE

FIGURE 18 GLOBAL CUMULATIVE INSTALLED BASE OF DNA SEQUENCERS, THROUGH APRIL 2010 (%)

SEQUENCE READ LENGTH

TABLE 18 READ LENGTHS FOR SELECTED SEQUENCING PLATFORMS

SEQUENCER PERFORMANCE SPACE

FIGURE 19 SEQUENCING COMPETITIVE MARKET SPACE

END-USER SWITCHING

PAIRED-END READS

TABLE 19 STRENGTHS AND LIMITATIONS OF PAIRED-END READS

BARCODING

DNA POLYMERASES

SEQUENCING BIOINFORMATICS

TABLE 20 INFORMATICS WORKFLOW FOR NEXT-GENERATION SEQUENCING

TECHNOLOGY CHALLENGES FOR NEXT-GENERATION PLATFORMS

TABLE 21 TECHNOLOGY CHALLENGES FOR NEXT-GENERATION SEQUENCING

CHAPTER FIVE: DNA SEQUENCING APPLICATIONS

INTRODUCTION

FIGURE 20 WHOLE GENOME SEQUENCING PROJECTS FOR PROKARYOTES AND EUKARYOTES, AS OF APRIL 2010 (NUMBER OF GENOMES SEQUENCED)

FIGURE 21 WHOLE GENOME SEQUENCING EUKARYOTIC PROJECTS, BY TYPE, AS OF APRIL 2010

RESEARCH AND DRUG DISCOVERY APPLICATIONS

INTRODUCTION

TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON

TABLE 23 SEQUENCING APPLICATIONS

TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS

DE NOVO SEQUENCING

De Novo Human Sequencing

De Novo Microbial Sequencing

TABLE 25 CASE STUDY 1: NEANDERTHAL DNA SEQUENCING

RESEQUENCING

Whole Genome Resequencing (Genome-wide Association Studies or Loci Discovery)

FIGURE 22 RELATIVE NUMBER OF DISEASE-CAUSING ALLELES AT MAF5 AND MAF1

FIGURE 23 SINGLE SEQUENCER, WHOLE GENOME THROUGHPUT TRENDS 1975-2015

Targeted Resequencing

SEQ-BASED METHODS

TABLE 26 GENETIC ANALYSIS APPLICATIONS WHERE SEQUENCING COMPETES WITH MICROARRAYS

Chromatin Immunoprecipitation Applications

TABLE 27 COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONS

DNase-seq

Gene Expression Analysis

TABLE 28 COMPARISON OF SEQUENCING AND MICROARRAYS FOR GENE EXPRESSION ANALYSIS

MethylSeq

DNA Mutation Studies

Complementary Sequencing and Microarray Platforms Drive Market Growth

DIAGNOSTICS AND DRUG DISCOVERY

FIGURE 24 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION

FIGURE 25 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION

PERSONAL GENOMICS

FIGURE 26 GENETIC ANALYSIS COST/INFORMATION CONTENT TRENDS

CHAPTER SIX: DNA SEQUENCING INITIATIVES

INTRODUCTION

FIGURE 27 NIH FUNDING AWARDS, BY INSTITUTE, FOR DNA SEQUENCING - RELATED PROJECTS, 2009-2010 (%)

NHGRI $1,000 GENOME PROJECT FUNDING

TABLE 29 NHGRI GRANTS UNDER $1,000 GENOME PROGRAM, FY2009 ($)

FIGURE 28 NHGRI $1,000 GENOME PROJECT AWARDS VALUE, FY2007- FY2009 ($ MILLIONS)

FIGURE 29 $1,000 GENOME PROJECT AWARDS, BY TECHNOLOGY, 2007-2009 (%)

SEQUENCING-RELATED GENOMICS PROJECTS OVERVIEW AND STATUS

TABLE 30 IMPORTANT SEQUENCING RESEARCH INITIATIVES

GENOME SEQUENCING PROJECTS

Functional Genomics in Norway (FUGE) II

Personal Genome Project

Archon X Prize in Genomics

Genomes 10K Project

1,000 Plant and Animal Reference Project

MEDICAL SEQUENCING PROJECTS

Mapped Autosomal Mendelian Disorders

Allelic Spectrum in Common Disease Program

Clinseq Project

CANCER SEQUENCING PROJECTS

Cancer Genome Project

Tumor Sequencing Project (TSP)

The Cancer Genome Atlas

MICROBIAL SEQUENCING PROJECTS

Human Microbiome Project

Microbial Genome Sequencing Project

Marine Microbial Genome Sequencing Project

Fungal Genome Initiative

Pathogen Sequencing Program

Genomic Encyclopedia of Bacteria and Archaea (GEBA)

Metagenomics of the Human Intestinal Tract (MetaHIT)

Gut Microbiome Initiative

10,000 Microbial Genomes Project

GENOME VARIATION PROJECTS

Encyclopedia of DNA Elements (ENCODE)

1,000 Genomes Project

1,000 Plant Genomes Project

Resequencing Technology Program

Human Genome Structural Variation Project

Yanhuang Project

AGRICULTURAL GENOMICS

National Plant Genome Initiative

EPIGENOMICS SEQUENCING PROJECTS

TABLE 31 EPIGENOMICS INITIATIVES

EUROPE

UNITED STATES

ASIA

IMPACT OF SEQUENCING PROJECTS

FIGURE 30 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK, 1988-2008 (BILLIONS)

CHAPTER SEVEN: DNA SEQUENCING INDUSTRY STRUCTURE

INDUSTRY STRUCTURE ANALYSIS

FIGURE 31 DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005

FIGURE 32 DNA SEQUENCING INDUSTRY STRUCTURE: POST 2005

TABLE 32 DNA SEQUENCING INDUSTRY TRANSITION

THE ROLE OF EARLY ADAPTORS

SEQUENCING INSTRUMENT COMPETITOR POSITIONING

FIGURE 33 SEQUENCER PLATFORM POSITIONING BY READS AND READ LENGTH

TABLE 33 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY

SEQUENCING SAMPLE PREPARATION INDUSTRY

TABLE 34 POSITIONING OF SEQUENCE ENRICHMENT FORMATS

TABLE 35 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING

SEQUENCING BIOINFORMATICS INDUSTRY

TABLE 36 DNA SEQUENCING BIOINFORMATICS COMPANY POSITIONING

SEQUENCING SERVICES INDUSTRY

TABLE 37 DNA SEQUENCING SERVICES COMPANY POSITIONING, BY MARKET FOCUS

SEQUENCING INSTRUMENTS COMPETITOR MARKET SHARES

FIGURE 34 ESTIMATED COMPETITOR MARKET SHARE: SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (%)

FIGURE 35 ESTIMATED COMPETITOR MARKET SHARE: SANGER SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (TOTAL MARKET $466.2 MILLION) (%)

FIGURE 36 ESTIMATED COMPETITOR MARKET SHARE: NEXTGENERATION SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (TOTAL MARKET $607.4 MILLION) (%)

INDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCES

TABLE 38 SEQUENCING INDUSTRY ACQUISITIONS, 2007-2010

TABLE 39 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2007-2010

SEQUENCING REAGENTS SUPPLY ALLIANCES

PERSONAL GENOMICS INDUSTRY DYNAMICS

TABLE 40 MEDIUM TO HIGH CONTENT DTC GENETIC TESTING KEY COMPETITORS

FIGURE 37 PERSONAL GENOMICS COMPETITIVE SPACE, BY TEST COST AND SCOPE

TABLE 41 PERSONAL GENOMICS COMPETITOR STRATEGIES

DNA SEQUENCING END USERS

TABLE 42 DNA SEQUENCING END-USER MARKET SEGMENTS

Major Sequencing Centers

TABLE 43 NEXT-GENERATION SEQUENCING INSTRUMENT INSTALLATIONS, BY MAJOR SEQUENCING CENTER, 2010

FIGURE 38 MAJOR SEQUENCING CENTER’S SHARE OF THE GENOME SEQUENCING PROJECTS MARKET BY NUMBER OF SEQUENCING PROJECTS, APRIL 2010 (%)

FIGURE 39 BEIJING GENOMICS INSTITUTE ADOPTION OF NEXTGENERATION SEQUENCERS, 2008 AND 2010 (NUMBER OF SEQUENCERS)

Large Core Sequencing Centers

TABLE 44 EXAMPLES OF LARGE CORE SEQUENCING CENTERS

Small to Mid-size Laboratories

Sequencing Service Laboratories

CHAPTER EIGHT: DNA SEQUENCING MARKETS

GROWTH DRIVING FORCES

TABLE 45 DNA SEQUENCING KEY GROWTH DRIVING FORCES

FIGURE 40 EUKARYOTIC SEQUENCING PARADIGM

GENETIC ANALYSIS MARKETS

TABLE 46 GLOBAL VALUE OF GENETIC ANALYSIS MARKET, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

FIGURE 41 SNP GENOTYPING MARKET

DNA SEQUENCING PRODUCTS MARKETS

DNA SEQUENCING MARKETS BY PRODUCT TYPE

TABLE 47 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 48 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENT AND CONSUMABLES MARKET, BY PRODUCT TYPE, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY SANGER AND NEXTGENERATION FORMATS

FIGURE 42 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND CONSUMABLES, BY TECHNOLOGY PLATFORM, 2010 AND 2015 (DOLLARS)

TABLE 49 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS, BY PLATFORM, THROUGH 2015 ($ MILLIONS)

TABLE 50 GLOBAL VALUE OF DNA SEQUENCING CONSUMABLES MARKET, BY PLATFORM, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY END USER

TABLE 51 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 52 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH 2015 ($ MILLIONS)

TABLE 53 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY TECHNOLOGY

TABLE 54 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY TECHNOLOGY, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY END-USER APPLICATION

TABLE 55 GLOBAL VALUE OF DNA SEQUENCING, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)

Research and Drug Discovery and Development

Forensic and Human ID

Bacterial Genomics

Agricultural Genomics

Clinical Diagnostics

TABLE 56 LABORATORIES DEVELOPING NEXT-GENERATION SEQUENCING DX TESTS

Personal Genomics

Other Applications

TABLE 57 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)

TABLE 58 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY GENOME TYPE

TABLE 59 GLOBAL VALUE OF SEQUENCING, BY GENOME TYPE, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY ANALYSIS TYPE

TABLE 60 GLOBAL VALUE OF DNA SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 61 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 62 GLOBAL VALUE OF SANGER SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

DNA SEQUENCING MARKETS BY GEOGRAPHY

TABLE 63 GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

TABLE 64 GLOBAL VALUE OF SANGER SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

TABLE 65 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

CHAPTER NINE: DNA SEQUENCING PATENT STATUS

RECENT PATENT ACTIVITY IN NEXT-GENERATION DNA SEQUENCING

TABLE 66 NEXT-GENERATION SEQUENCING PATENT RECENT ACTIVITY

Sequencing by Synthesis

Single-molecule Sequencing

Nanopore Sequencing

Polony Sequencing

Nucleotide Modifications and Analogs

DNA Polymerases

Paired-end Inventions

Other Methods

PATENT POSITION OF SEQUENCING COMPETITORS

FIGURE 43 SEQUENCING-RELATED PATENTS, BY COMPANY (NUMBER OF PATENTS)

TECHNOLOGY DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS

FIGURE 44 GLOBAL NEXT-GENERATION SEQUENCING PATENTS, BY TECHNOLOGY, 2001-2009

GEOGRAPHICAL DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS

FIGURE 45 GLOBAL NEXT-GENERATION SEQUENCING-RELATED PATENTS, BY GEOGRAPHY, 2000-2009 (NUMBER OF PATENTS)

SEQUENCING LITIGATION STATUS

TABLE 67 SEQUENCING IP LITIGATION STATUS

INTELLECTUAL PROPERTY POSITION OF SELECTED SEQUENCING COMPANIES

LIFE TECHNOLOGIES

LI-COR BIOSCIENCES

HELICOS BIOSCIENCES

ILLUMINA

INTELLIGENT BIO-SYSTEMS

PACIFIC BIOSCIENCES

CHAPTER TEN: COMPANY PROFILES

23ANDME

AFFOMIX CORPORATION

AFFYMETRIX, INC.

AGILENT TECHNOLOGIES, INC.

ARTEMIS HEALTH, INC.

BASE4INNOVATION, LTD.

BECKMAN COULTER

BIO.LOGIS CENTER FOR HUMAN GENETICS

BIONANOMATRIX, INC.

BIOTIQUE SYSTEMS INC.

CALIPER LIFE SCIENCES

COLLABRX, INC.

COMPLETE GENOMICS, INC.

CONEXIO GENOMICS

CORRELAGEN DIAGNOSTICS, INC.

DANAHER MOTION

DECODEME

DELTADOT, LTD.

DNANEXUS, INC.

DNA STAR, INC.

ELECTRONIC BIOSCIENCES

EUROFINS MEDIGENOMIX GMBH

EXPRESSION ANALYSIS, INC.

FASTERIS SA

FEBIT BIOTECH GMBH

FIREBIRD BIOMOLECULAR SCIENCES, LLC

FLUIDIGM CORPORATION

FOUNDATION FOR APPLIED MOLECULAR EVOLUTION

GATC BIOTECH AG

GE HEALTHCARE

GENEDATA AG

GENOME DIAGNOSTICS B.V

GENOMEQUEST, INC.

GENOMATIX SOFTWARE, INC.

GENOVOXX GMBH

GEOSPIZA, INC.

HALCYON MOLECULAR

HELICOS BIOSCIENCES CORPORATION

INTERNATIONAL BUSINESS MACHINES CORP.

ILLUMINA, INC.

TABLE 68 ILLUMINA SEQUENCING TECHNOLOGY SPACE

INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

INTELLIGENT BIO-SYSTEMS

INTERNA GENOMICS BV

ION TORRENT SYSTEMS

IP GENESIS INC.

ISENTIO AS

KNOME, INC.

LASERGEN, INC.

LI-COR BIOSCIENCES

LIFE TECHNOLOGIES, INC.

LIFECODEXX

LIGHTSPEED GENOMICS

LINGVITAE AS

MICROCHIP BIOTECHNOLOGIES, INC.

MWG BIOTECH AG

MYCROARRAY.COM

NABSYS, INC.

NAVIGENICS

NETWORK BIOSYSTEMS

NEWGENE, LTD.

NUGEN TECHNOLOGIES, INC.

OLINK GENOMICS AB

OPGEN, INC.

OXFORD NANOPORE TECHNOLOGIES

PACIFIC BIOSCIENCES

POPULATION GENETICS TECHNOLOGIES, LTD.

QUANTALIFE, INC.

RAINDANCE TECHNOLOGIES, INC.

REAL TIME GENOMICS

REVEO INC.

ROCHE LIFE SCIENCES

SEIRAD, INC.

SEQUENOM, INC.

SEQWRIGHT

SHIMADZU SCIENTIFIC INSTRUMENTS

SMARTGENE

SOURCE BIOSCIENCES, PLC.

SORENSON GENOMICS

U.S. GENOMICS

VISIGEN BIOTECHNOLOGIES, INC.

X-PRIZE FOUNDATION

ZS GENETICS

LIST OF TABLES

SUMMARY TABLE GLOBAL VALUE OF DNA SEQUENCING

PRODUCTS, BY END-USE APPLICATION, THROUGH 2015 ($

MILLIONS)

TABLE 1 SCOPE OF THIS REPORT

TABLE 2 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW

PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 3 DNA SEQUENCING KEY GROWTH DRIVING FORCES

TABLE 4 PRODUCT LIFE CYCLE STATUS OF SEQUENCING

PLATFORMS

TABLE 5 SEQUENCING INSTRUMENT COMPETITORS, BY

TECHNOLOGY

TABLE 6 SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIES

TABLE 7 DNA SEQUENCING HISTORICAL TIMELINE

TABLE 8 DNA SEQUENCING TECHNOLOGY PLATFORM

COMPARISON

TABLE 9 LIMITATIONS OF SANGER SEQUENCING TECHNOLOGY

TABLE 10 IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY

TABLE 11 NEXT-GENERATION SEQUENCING WORKFLOW STEPS

TABLE 12 WORKFLOW COMPARISON OF SELECTED NEXTGENERATION

DNA SEQUENCING PLATFORMS

TABLE 13 NEXT-GENERATION SEQUENCE PLATFORMS

TABLE 14 NEXT-GENERATION SEQUENCING PLATFORM

ADVANTAGES AND LIMITATIONS

TABLE 15 KEY PERFORMANCE METRICS FOR SEQUENCING

TECHNOLOGIES

TABLE 16 COST AND PERFORMANCE COMPARISON OF SELECTED

NEXT- AND THIRD-GENERATION DNA SEQUENCING PLATFORMS

TABLE 17 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES

TABLE 18 READ LENGTHS FOR SELECTED SEQUENCING

PLATFORMS

TABLE 19 STRENGTHS AND LIMITATIONS OF PAIRED-END READS

TABLE 20 INFORMATICS WORKFLOW FOR NEXT-GENERATION

SEQUENCING

TABLE 21 TECHNOLOGY CHALLENGES FOR NEXT-GENERATION

SEQUENCING

TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON

TABLE 23 SEQUENCING APPLICATIONS

TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS

TABLE 25 CASE STUDY 1: NEANDERTHAL DNA SEQUENCING

TABLE 26 GENETIC ANALYSIS APPLICATIONS WHERE SEQUENCING

COMPETES WITH MICROARRAYS

TABLE 27 COMPARISON OF SEQUENCING WITH MICROARRAYS FOR

CHIP APPLICATIONS

TABLE 28 COMPARISON OF SEQUENCING AND MICROARRAYS FOR

GENE EXPRESSION ANALYSIS

TABLE 29 NHGRI GRANTS UNDER $1,000 GENOME PROGRAM, FY2009

($)

TABLE 30 IMPORTANT SEQUENCING RESEARCH INITIATIVES

TABLE 31 EPIGENOMICS INITIATIVES

TABLE 32 DNA SEQUENCING INDUSTRY TRANSITION

TABLE 33 SEQUENCING INSTRUMENT COMPETITORS, BY

TECHNOLOGY

TABLE 34 POSITIONING OF SEQUENCE ENRICHMENT FORMATS

TABLE 35 SEQUENCING SAMPLE PREPARATION COMPANY

POSITIONING

TABLE 36 DNA SEQUENCING BIOINFORMATICS COMPANY

POSITIONING

TABLE 37 DNA SEQUENCING SERVICES COMPANY POSITIONING,

BY MARKET FOCUS

TABLE 38 SEQUENCING INDUSTRY ACQUISITIONS, 2007-2010

TABLE 39 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2007-

2010

TABLE 40 MEDIUM TO HIGH CONTENT DTC GENETIC TESTING KEY

COMPETITORS

TABLE 41 PERSONAL GENOMICS COMPETITOR STRATEGIES

TABLE 42 DNA SEQUENCING END-USER MARKET SEGMENTS

TABLE 43 NEXT-GENERATION SEQUENCING INSTRUMENT

INSTALLATIONS, BY MAJOR SEQUENCING CENTER, 2010

TABLE 44 EXAMPLES OF LARGE CORE SEQUENCING CENTERS

TABLE 45 DNA SEQUENCING KEY GROWTH DRIVING FORCES

TABLE 46 GLOBAL VALUE OF GENETIC ANALYSIS MARKET, BY

ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 47 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW

PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 48 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENT AND

CONSUMABLES MARKET, BY PRODUCT TYPE, THROUGH 2015 ($

MILLIONS)

TABLE 49 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS, BY

PLATFORM, THROUGH 2015 ($ MILLIONS)

TABLE 50 GLOBAL VALUE OF DNA SEQUENCING CONSUMABLES

MARKET, BY PLATFORM, THROUGH 2015 ($ MILLIONS)

TABLE 51 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS

AND CONSUMABLES, BY CUSTOMER TYPE, THROUGH 2015 ($

MILLIONS)

TABLE 52 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS

AND CONSUMABLES, BY CUSTOMER, THROUGH 2015 ($

MILLIONS)

TABLE 53 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING

INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH

2015 ($ MILLIONS)

TABLE 54 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS

AND CONSUMABLES MARKET, BY TECHNOLOGY, THROUGH 2015

($ MILLIONS)

TABLE 55 GLOBAL VALUE OF DNA SEQUENCING, BY END-USE

APPLICATION, THROUGH 2015 ($ MILLIONS)

TABLE 56 LABORATORIES DEVELOPING NEXT-GENERATION

SEQUENCING DX TESTS

TABLE 57 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING

INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION,

THROUGH 2015 ($ MILLIONS)

TABLE 58 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS

AND CONSUMABLES, BY END-USE APPLICATION, THROUGH 2015

($ MILLIONS)

TABLE 59 GLOBAL VALUE OF SEQUENCING, BY GENOME TYPE,

THROUGH 2015 ($ MILLIONS)

TABLE 60 GLOBAL VALUE OF DNA SEQUENCING, BY ANALYSIS

TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 61 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING, BY

ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 62 GLOBAL VALUE OF SANGER SEQUENCING, BY ANALYSIS

TYPE, THROUGH 2015 ($ MILLIONS)

TABLE 63 GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY

GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

TABLE 64 GLOBAL VALUE OF SANGER SEQUENCING PRODUCTS, BY

GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)

TABLE 65 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING

PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($

MILLIONS)

TABLE 66 NEXT-GENERATION SEQUENCING PATENT RECENT

ACTIVITY

TABLE 67 SEQUENCING IP LITIGATION STATUS

TABLE 68 ILLUMINA SEQUENCING TECHNOLOGY SPACE

LIST OF FIGURES

SUMMARY FIGURE GLOBAL VALUE OF DNA SEQUENCING

PRODUCTS, BY END-USE APPLICATION, 2009-2015 ($ MILLIONS)

FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA

FIGURE 2 DNA, MRNA, AND GENETIC VARIATION

FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED PER

DOLLAR

FIGURE 4 SEQUENCING THROUGHPUT TREND

FIGURE 5 HUMAN GENOME SEQUENCING COST TREND (DOLLARS)

FIGURE 6 $1,000 GENOME PRODUCT SPACE

FIGURE 7 DDNTP CHEMICAL STRUCTURE

FIGURE 8 SANGER SEQUENCING WORKFLOW

FIGURE 9 COST BREAKDOWN FOR SEQUENCING A SINGLE HUMAN

GENOME, USING 2005 SANGER SEQUENCER TECHNOLOGY (%)

FIGURE 10 NEXT-GENERATION SEQUENCING TECHNOLOGIES

FIGURE 11 SCHEMATIC COMPARISON OF ROCHE/454, LIFE

TECHNOLOGIES, AND ILLUMINA SEQUENCING PLATFORMS

FIGURE 12 SEQUENCING BY SYNTHESIS: REVERSIBLE

TERMINATOR REACTION

FIGURE 13 SEQUENCING BY SYNTHESIS: PYROSEQUENCING

REACTION

FIGURE 14 SCHEMATIC OF SOLID SEQUENCING BY LIGATION

FIGURE 15 DECODING SOLID COLOR DATA

FIGURE 16 SINGLE-MOLECULE SEQUENCING BY SYNTHESIS

FIGURE 17 NANOPORE SEQUENCING WORKFLOW AND

TECHNOLOGY APPROACHES

FIGURE 18 GLOBAL CUMULATIVE INSTALLED BASE OF DNA

SEQUENCERS, THROUGH APRIL 2010 (%)

FIGURE 19 SEQUENCING COMPETITIVE MARKET SPACE

FIGURE 20 WHOLE GENOME SEQUENCING PROJECTS FOR

PROKARYOTES AND EUKARYOTES, AS OF APRIL 2010 (NUMBER

OF GENOMES SEQUENCED)

FIGURE 21 WHOLE GENOME SEQUENCING EUKARYOTIC PROJECTS,

BY TYPE, AS OF APRIL 2010

FIGURE 22 RELATIVE NUMBER OF DISEASE-CAUSING ALLELES AT

MAF5 AND MAF1

FIGURE 23 SINGLE SEQUENCER, WHOLE GENOME THROUGHPUT

TRENDS 1975-2015

FIGURE 24 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY

COMPETITION

FIGURE 25 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY

COMPETITION

FIGURE 26 GENETIC ANALYSIS COST/INFORMATION CONTENT

TRENDS

FIGURE 27 NIH FUNDING AWARDS, BY INSTITUTE, FOR DNA

SEQUENCING - RELATED PROJECTS, 2009-2010 (%)

FIGURE 28 NHGRI $1,000 GENOME PROJECT AWARDS VALUE,

FY2007- FY2009 ($ MILLIONS)

FIGURE 29 $1,000 GENOME PROJECT AWARDS, BY TECHNOLOGY,

2007 THROUGH 2009 (%)

FIGURE 30 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK, 1988-

2008 (BILLIONS)

FIGURE 31 DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005

FIGURE 32 DNA SEQUENCING INDUSTRY STRUCTURE: POST 2005

FIGURE 33 SEQUENCER PLATFORM POSITIONING BY READS AND

READ LENGTH

FIGURE 34 ESTIMATED COMPETITOR MARKET SHARE:

SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (%)

FIGURE 35 ESTIMATED COMPETITOR MARKET SHARE: SANGER

SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (TOTAL

MARKET $466.2 MILLION) (%)

FIGURE 36 ESTIMATED COMPETITOR MARKET SHARE: NEXTGENERATION

SEQUENCING INSTRUMENTS AND REAGENTS, 2009

(TOTAL MARKET $607.4 MILLION) (%)

FIGURE 37 PERSONAL GENOMICS COMPETITIVE SPACE, BY TEST

COST AND SCOPE

FIGURE 38 MAJOR SEQUENCING CENTER’S SHARE OF THE GENOME

SEQUENCING PROJECTS MARKET BY NUMBER OF SEQUENCING

PROJECTS, APRIL 2010 (%)

FIGURE 39 BEIJING GENOMICS INSTITUTE ADOPTION OF NEXTGENERATION

SEQUENCERS, 2008 AND 2010 (NUMBER OF

SEQUENCERS)

FIGURE 40 EUKARYOTIC SEQUENCING PARADIGM

FIGURE 41 SNP GENOTYPING MARKET

FIGURE 42 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND

CONSUMABLES, BY TECHNOLOGY PLATFORM, 2010 AND 2015

(DOLLARS)

FIGURE 43 SEQUENCING-RELATED PATENTS, BY COMPANY

(NUMBER OF PATENTS)

FIGURE 44 GLOBAL NEXT-GENERATION SEQUENCING PATENTS, BY

TECHNOLOGY, 2001-2009

FIGURE 45 GLOBAL NEXT-GENERATION SEQUENCING-RELATED

PATENTS, BY GEOGRAPHY, 2000-2009 (NUMBER OF PATENTS)

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DNA Sequencing: Emerging Technologies and Applications

Market Study Published: July 2010 Pages: 297 Tables: 68 From: GBP 3344.00 Buy Now! Research from: Business Communications Company Inc. Sector: Biotechnology

Market Study
Published: July 2010
Pages: 297
Tables: 68
From: GBP 3344.00 Buy Now!
Research from: Business Communications Company Inc.
Sector: Biotechnology