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Table of Contents

Market Study
Published: June 2010
Pages: 94
Tables: For full details, please email keithw@cmsinfo.com
From: GBP 2556.67  Buy Now!
Research from: pharmaceuticalmarketresearch
Sector: Biotechnology

Table of Contents

Table of Contents
Opportunities in Non-surgical Bio-implants Executive summary 10
Injectable biomaterials 10
Viscoaugmentation 11
Viscosupplementation 12
Alloplastic injectable biomaterials: R&D 13
Chapter 1 Injectable biomaterials 16
Summary 16
Introduction 17
Development issues 18
Problems with biocompatibility 18
Design factors 20
Rationale for development of injectable biomaterials 22
Types of injectable biomaterials 22
Collagen 23
Hyaluronic acid 24
Hydrogels 25
Hydroxyapatite 26
Calcium phosphate ceramic pastes 27
Biopolymers 27
Adverse reactions associated with current injectable biomaterials 28
Ideal properties of injectable biomaterials 29
Chapter 2 Viscoaugmentation 32
Summary 32
Soft tissue viscoaugmentation bio-implants 33
Trends in injectable cosmetic treatments in the US 33
Primary indications for soft-tissue augmentation products 34
Collagen 35
Companies, products, and market activities 36
Allergan’s Zyderm-Zyplast/Cosmoderm-Cosmoplast range 36
Recent industry activities: Evolence discontinued 37
Hyaluronic acid 38
Companies, products, and market activities 39
Adoderm 39
Allergan 39
Anteis 41
Anika Therapeutics 42
BioPolymer GmbH & Co. KG 43
Coapt Systems 45
Fidia Farmaceutici 46
KuhraVital Dermapharma 46
Laboratoires Filorga 46
L&M Aesthetic Equipment/Parpas Group 47
LCA Pharmaceutical 47
Hangzhou Gallop Biological Products 48
Novatex Bioengineering/Laboratoires Orgév 49
Johnson & Johnson/Mentor Corp. 50
Puragen 50
Merz Pharma/Merz Aesthetics 51
Q-Med 52
Nordic Aesthetics 54
Prollenium Medical Technologies 55
Rofil Medical/Philoderm Aesthetics 56
Teoxane Laboratoires 56
Biopolymers 57
Dimethicone/silicone oil 57
Companies, products, and market activities 58
Contura International 58
FzioMed 60
Polymekon 60
Suneva 61
ProCytech 62
Sanofi-Aventis 63
Generic polymeric soft tissue fillers 63
Ceramics/hybrid technologies 64
Companies, products, and market activities 64
BioForm Medical 64
Stiefel Laboratories/GlaxoSmithKline 65
Chapter 3 Viscosupplementation 68
Summary 68
Intra-articular injectable bio-implants 69
Marketed injectable products and company activities 70
Anika Therapeutics 70
Anteis 71
BioPolymer 71
Curasan 72
Ferring Pharmaceuticals 72
Fidia Farmaceutici 73
Genzyme Corp 73
LCA Pharmaceutical 74
Novatex Bioengineering 75
Ortho Biotech/Johnson & Johnson/Anika Therapeutics 76
Q-Med/Smith & Nephew 76
Sanofi-Aventis 77
Seikagaku/Smith & Nephew 77
TRB Chemedica 78
Generic sodium hyaluronate 79
Chapter 4 Alloplastic injectablebiomaterials: R&D 82
Summary 82
Alloplastic injectable biomaterials: current R&D 83
Viscoaugmentation: cosmetic applications 83
Albiorex 83
FibroGen 84
Kythera Pharmaceuticals 84
Moma Therapeutics 84
Novatex Bioengineering 85
Prollenium Medical Technologies 85
Viscosupplementation: medical/surgical applications 85
Anika Therapeutics 86
Barrow Neurological Institute at St. Joseph’s Hospital and Medical
Center, US 86
Biotechnology Institute IMASD 87
Genzyme Corp 87
Pioneer Surgical Technology 87
Prollenium Medical Technologies 88
Seikagaku 88
Considerations, insights, and recommendations 89
Appendix 91
Scope 91
Methodology 91
Glossary 92
Index 94
List of Figures
Figure 1.1: Potential adverse responses to implanted biomaterials 19
Figure 1.2: Essential design components for biocompatibility of implantable biomaterials 20
Figure 1.3: Types of marketed injectable biomaterials 23
Figure 1.4: Medical applications and benefits of hydrogels 26
Figure 1.5: Potential adverse reactions associated with injectable biomaterials 29
Figure 2.6: Trends in injectable treatments in the US, 2003–2009 34
Figure 2.7: Primary indications for soft tissue dermal fillers 35
List of Tables
Table 1.1: Basic properties and medical applications of biomaterials 18
Table 1.2: Medical applications of hyaluronic acid 25
Table 1.3: Medical applications of biopolymers 28
Table 2.4: Marketed collagen-based injectable products 36
Table 2.5: Main indications for Allergan’s collagen-based injectable products 37
Table 2.6: Adoderm’s hyaluronic acid-based injectable products 39
Table 2.7: Allergan’s hyaluronic acid-based injectable products 41
Table 2.8: Anteis’ hyaluronic acid-based injectable products 42
Table 2.9: Anika Therapeutics’ hyaluronic acid-based injectable products 43
Table 2.10: Biopolymer’s marketed hyaluronic acid-based injectable products 44
Table 2.11: Coapt Systems’ marketed hyaluronic acid-based injectable products 45
Table 2.12: KuhraVital’s marketed hyaluronic acid-based injectable products 46
Table 2.13: Laboratoires Filorga’s marketed hyaluronic acid-based injectable products 47
Table 2.14: L&M Aesthetic’s marketed hyaluronic acid-based injectable products 47
Table 2.15: LCA Pharma’s marketed hyaluronic acid-based injectable products 48
Table 2.16: HGBP’s marketed hyaluronic acid-based injectable products 49
Table 2.17: Novatex’s hyaluronic acid-based injectable products 50
Table 2.18: J&J’s marketed hyaluronic acid-based injectable products 50
Table 2.19: Merz Pharma’s marketed hyaluronic acid-based injectable products 51
Table 2.20: Q-Med’s marketed hyaluronic acid-based injectable products 52
Table 2.21: Nordic Aesthetics’ marketed hyaluronic acid-based injectable products 54
Table 2.22: Prollenium’s marketed hyaluronic acid-based injectable products 55
Table 2.23: Rofil Medical/Philiderm Aesthetics’ marketed hyaluronic acid-based injectable products 56
Table 2.24: Teoxane’s marketed hyaluronic acid-based injectable products 57
Table 2.25: Contura’s marketed polymer-based injectable products 59
Table 2.26: FzioMed’s marketed polymer-based injectable products 60
Table 2.27: Polymekon’s marketed polymer-based injectable products 60
Table 2.28: Suneva’s marketed polymer-based injectable products 62
Table 2.29: ProCytech’s marketed polymer-based injectable products 62
Table 2.30: Sanofi-Aventis’ marketed polymer-based injectable products 63
Table 2.31: BioForm Medical’s injectable ceramic-based products 65
Table 2.32: Stiefel Laboratories/GSK’s injectable ceramic-based products 66
Table 3.33: Application of biomaterials for orthopedic applications 69
Table 4.34: Selected allosteric viscoaugmentation products in development 83
Table 4.35: Selected allosteric viscosupplementation products in development 86

For full details, please email keithw@cmsinfo.com

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